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High Quality Content by WIKIPEDIA articles! The Diocletianic Persecution (or Great Persecution) was the last and most severe persecution of Christians in the Roman empire. In 303, Emperor Diocletian and Maximian, Galerius, and Constantius issued a series of edicts rescinding the legal rights of Christians and demanding that they comply with traditional Roman religious practices. Later edicts targeted the clergy and demanded universal sacrifice, ordering all inhabitants to sacrifice to the gods. The persecution varied in intensity across the empire-weakest in Gaul and Britain, where only the first edict was applied, and strongest in the Eastern provinces. Persecutory laws were nullified by different emperors at different times, but Constantine and Liciniuss Edict of Milan (313) has traditionally marked the end of the persecution.